Proteolysis targeting chimera compounds and methods of preparing and using same

• 收藏
• 分享

专利权人:

Yale University

发明人:

Crews, Craig,Toure, Momar,Ko, Eunhwa,Jaime-Figueroa, Saul

申请号：

AU2016349781

公开号：

AU2016349781A1

申请日:

2016.11.02

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The present invention includes novel compounds and methods for preventing or treating diseases associated with and/or caused by overexpression and/or uncontrolled activation of a tyrosine kinase in a subject in need thereof. In certain embodiments, the compounds of the present invention comprise a tyrosine kinase inhibitor, a linker and a ubiquitin ligase binder. The methods of the present invention comprise administering to the subject an pharmaceutically effective amount of at least one compound of the invention.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/