REMICK, David Michael,RICHARDS, Simon James,SANDERSON, Adam Jan
申请号：
PE2017001998
公开号：
PE20180048A1
申请日:
2016.04.22
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
It refers to compound n - [3 - [(4As, 5S, 7As) - 2-amino-5 - (1, 1-difluoroethylene) - 4, 4a, 5, 7-tetrahydrofuran [3, 4-d] [1, 3] tiyaxin-7a-il] - 4-fluoro-phenyl] - 5-cyanopyridine-2-amino or a salt from which drug acceptance can be obtained. A drug synthesis and preparation procedure was also mentioned. This compound is an inhibitor of the b-secretariat (protein separating enzyme, amide precursor of site B； homogenous bacilli bae1) and is useful in the treatment of Alzheimer's disease.Se refiere al compuesto N-[3-[(4aS,5S,7aS)-2-amino-5-(1,1-difluoroetil)-4,4a,5,7-tetrahidrofuro[3,4-d][1,3]tiazin-7a-il]-4-fluoro-fenil]-5-ciano-piridin-2-carboxamida o una sal farmaceuticamente aceptable del mismo. Tambien esta referida a una composicion farmaceutica y a un procedimiento de preparacion. Dicho compuesto es inhibidor de B-secretasa (enzima de escision de proteina precursora de amiloide del sitio B； homologo BACE1) y es util en el tratamiento de la enfermedad de Alzheimer
