NOVEL 3 (4 (BENZYLOXY)PHENYL)HEX 4 INOIC ACID DERIVATIVE METHOD OF PREPARING SAME AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING METABOLIC DISEASE INCLUDING SAME AS EFFECTIVE INGREDIENT
YANG JIN,KIM JIN WOONG,LEE HAN KYU,KIM JAE HYUN,SON CHANG MO,LEE KYU HWAN,CHOI HYUNG-HO,KIM DAEHOON,HA TAE-YOUNG,RHEE JAEKEOL
申请号：
IN2836/MUMNP/2015
公开号：
IN2015MN02836A
申请日:
2015.09.30
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
in vivoThe present invention relates to a novel 3 (4 (benzyloxy)phenyl)hex 4 inoic acid derivative a method of preparing same and a pharmaceutical composition for preventing and treating metabolic disease including same as an effective ingredient. The novel 3 (4 (benzyloxy)phenyl)hex 4 inoic acid derivative an optical isomer thereof or a pharmaceutically acceptable salt thereof according to the present invention has an excellent effect on activation of GPR40 protein and thus has excellent promoting effect of insulin secretion is nontoxic when co administrated with other drugs and is possibly co administrated with other drugs and has excellent effective effect of activating GPR40 protein . Therefore a composition including the novel 3 (4 (benzyloxy)phenyl)hex 4 inoic acid derivative the optical isomer thereof or the pharmaceutically acceptable salt thereof may be availably used in a pharmaceutical composition for preventing and treating metabolic disease such as obesity type I diabetes type II diabetes incompatible glucose tolerance insulin tolerance hyperglycemia hyperlipidemia hypertriglyceridemia hypercholesterolemia dyslipidemia syndrome X etc.
