The Invention relates to the field of chemical medicines, and particularly toapurinyl-N-hydroxyl pyrimidine formamide derivative, preparation methods andusesthereof. The Invention provides a purinyl-N-hydroxyl pyrimidine formamidederivative with a structure shown in Formula I. The Invention also providespreparation methods and uses of said purinyl-N-hydroxyl pyrimidine formamidederivative. The purinyl-N-hydroxyl pyrimidine formamide derivative provided intheInvention can be not only a kinase inhibitor with PI3K and HDAC difunctionaltargets,but also a kinase inhibitor with single PI3K or HDAC functional target, thusproviding a new choice for preparing multi-target inhibitors.(see formula I)