The present invention relates to chemicals, in particular to a purinyl-N- hydroxyls pyrimidine carboxamide derivatives, the preparation method of material and its field that uses. The present invention provides the hydroxyl pyrimidine carboxamide derivatives that a purinyl-N- has structure shown in a formula I. The present invention also provides the preparation method and use of the material of the purinyl-N- hydroxyls pyrimidine carboxamide derivatives. Purinyl-N- hydroxyl pyrimidine carboxamide derivatives provided by the present invention can be not only the kinase inhibitor with the double-acting targets of PI3K and HDAC with single PI3K or HDAC targets, and a kinase inhibitor, to provide the new selection for being used to prepare multiple target inhibitor.
