The purpose of the present invention is to propose a composition which comprises earthworm as an active ingredient and can inhibit fatty liver and nephromegaly that are likely induced by diabetes. The composition, which inhibits fatty liver and nephromegaly caused by diabetes, is prepared by: inoculating a fruit and vegetable extract with yeasts to give a fermented liquor； adding earthworms to the fermented liquor and fermenting the earthworms to give fermented earthworms； adding, to the fermented earthworms, Panax notoginseng followed by fermenting and drying to give a fermented mixture； and mixing the fermented mixture with ants and gingko leaves.
