Wake Forest University Health Sciences;UAB Research Foundation
发明人:
申请号：
EP16873727.8
公开号：
EP3386967A4
申请日:
2016.12.07
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Provided herein are methods of treatment for kidney stones, e.g., for controlling or inhibiting the formation of calcium oxalate kidney stones by inhibiting the production of glyoxylate and/or oxalate, treatment of primary hyperoxaluria, etc. In some embodiments, methods comprise administering to a subject in need thereof, in combination, an inhibitor of hydroxyproline dehydrogenase (HYPDH), an inhibitor of glycolate oxidase (GO), and/or another agent for the treatment of kidney stones. Compositions for such use or the use of active agents in the manufacture of a medicament for the treatment of kidney stones are also provided.
