ВЕНКАТРАМАН Срипатхи (US),МАХМУД Сайед (US),МОБЕЛЕ Бингидими И. (US),ЛАПИНА Ольга (US),ВЕРКОЕ Келли (US),ЛИ Ин (US),СЭЛСБЕРИ Джонатан (US),МАКЛОУС Марк (US)
申请号：
RU2012111227/04
公开号：
RU2012111227A
申请日:
2010.08.24
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A process for preparing a compound of the formula: in which R is alkyl； R is H or alkyl； each R and R is independently alkyl, alkenyl, halogen, aryl, heteroaryl, arylalkyl, heteroarylalkyl, NR, SR or OR, where R is alkyl or aryl； n is 0, 1 or 2； m is 0, 1, 2 or 3； comprising the interaction of a compound of the formula wherein R, R, m and n are as defined for formula (1) and L is a leaving group with a compound of the formula R and R are as defined for formula (1) .2. The method according to claim 1, wherein the compound of formula (2) is prepared by reacting a compound of the formula wherein R and n are as defined for formula (1) and L is a leaving group with a compound of the formula R and m are as defined for formula ( 1), and L 'represents a leaving group, or with a compound of the formula to form an imine, followed by reduction of the indicated imine. 3. The method of claim 2, wherein the compound of formula (3) is prepared by reacting a compound of the formula wherein R and n are as defined for formula (1) and L is a leaving group, with a compound of the formula wherein Pr is a protecting group, in the presence of an agent, contributing to the formation of a peptide bond, followed by removal of the protective group； or by selectively linking a compound of formula (4) to piperazine without a protecting group； or by converting a compound of formula (4) to benzoyl chloride and attaching chloride to a compound of formula followed by deprotection. 4. The method according to claim 1 or 2, where m and n are equal to 0.5. The method according to claim 1 or 2, where R and / or R is alkyl. The method according to claim 1 or 2,1. Способ получения соединения формулы:в которойRпредставляет собой алкил；Rявляется H или алкилом；каждый Rи Rявляется независимо алкилом, алкенилом, галогеном, арилом, гетероарилом, арилалкилом, гетероарилалкилом, NR, SR или OR, где R означает алкил или арил；n составляет 0, 1 или 2；m составляет 0, 1, 2 или 3；включающий взаимодействие соединения
