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Process for preparing AD-35
专利权人:
Zhejiang Hisun Pharmaceutical Co.; Ltd.
发明人:
Jinqing Zhong,Xuyang Zhao,Hua Bai,Yongxiang Gong,Xinlong Zhang,Qifeng Zhu,Weiwei Liu,Ya Zhou
申请号:
US16087308
公开号:
US10399992B2
申请日:
2017.03.28
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention involves: using piperic acid as a raw material; and performing bromination, esterification, cyanidation, cyclopropane lactamization, amide nitrogen alkylation, deprotection, piperidine nitrogen alkylation and salification to obtain the compound of Formula (I). The method has cheap and easily available start raw materials, short synthesis routes and simple operation, and is suitable for industrial production.
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