A kind of method that is used to make the different glutamyl of the D--D-tryptophane of pure crystalline state is provided it comprises the step of the different glutamyl of pure basically uncle N--butoxy carbonyl-D--D-tryptophane or its diester being carried out deprotection, to produce the pure basically different glutamyl of D--D-tryptophane.Also providing a kind of is used for from the method for the pure mono-ammonium of the different glutamyl of the pure basically uncle N--butoxy carbonyl-D--different glutamyl of D-tryptophane preparation D--D-tryptophane.The different glutamyl of D--D-tryptophane, ammonium salt (1: 1) are a kind of stable medical solids.