THE CHILDREN'S HOSPITAL OF PHILADELPHIA;THE CHILDRENS HOSPITAL OF PHILADELPHIA
发明人:
ISCHIROPOLOUS, Harry,DOULIAS, Paschalis-Thomas
申请号：
USUS2014/048564
公开号：
WO2015/017383A3
申请日:
2014.07.29
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Compositions and methods for inhibiting, treating, and/or preventing fatty acid metabolism disorders, particularly fatty acid oxidation disorders, in a subject are provided. The method comprises administering at least one S-nitrosylating agent to the subject. In a particular embodiment, the fatty acid oxidation disorder is very long-chain acyl-coenzyme A dehydrogenase deficiency (VLCADD). In a particular embodiment, the S-nitrosylating agent is S-nitroso-Nacetyl-cysteine (SNO-NAC).L'invention concerne des compositions et des procédés pour inhiber, traiter et/ou prévenir des troubles du métabolisme des acides gras, en particulier des troubles de l'oxydation des acides gras, chez un sujet.
