Compositions and methods for inhibiting, treating, and/or preventing fatty acid metabolism disorders, particularly fatty acid oxidation disorders, in a subject are provided. The method comprises administering at least one S-nitrosylating agent to the subject. In a particular embodiment, the fatty acid oxidation disorder is very long-chain acyl-coenzyme A dehydrogenase deficiency (VLCADD). In a particular embodiment, the S-nitrosylating agent is S-nitroso-Nacetyl-cysteine (SNO-NAC).
