Thomas A. Steitz,Peter B. Moore,Joyce A. Sutcliffe,Adegboyega K. Oyelere,Joseph A. Ippolito
申请号：
US13924155
公开号：
US08912150B2
申请日:
2013.06.21
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
