596626 Synthesis of sialic acid in plants Provided is a method of synthesizing sialic acid comprising, i) providing a transgenic plant comprising a nucleotide sequence encoding microbial NeuSAc lyase, the nucleotide sequence operatively linked with a regulatory region that is active in the plant, and ii) growing the transgenic plant and expressing the nucleotide sequence thereby synthesizing sialic acid. The transgenic plants can be used to produce sialylated proteins of interest for oral therapeutics.