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Substituted morpholine derivatives that have activity against the pain
专利权人:
LABORATORIOS DEL DR. ESTEVE; S.A.
发明人:
申请号:
ARP160103226
公开号:
AR106445A1
申请日:
2016.10.21
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
1. Claim 1: a general formula compound (1),R1 is an equation compound (2) or (3);M is 1, 2, 3, 4 or 5; n is 0, 1, 2, 3, 4 or 5; P is 0 or 1; q is 0, 1 or 2; R is 0, 1 or 2; and es-ch-83222-o-c (o));X is a link, - C (r739; - r739 '),-C (O) -- that is...-C (o) 8311 -,-No. 8311; (c) (o) - O-C (o) O -;where Rˣ is selected from halogen, or substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₂₋₆ alkenyl, substituted or unsubstituted C₂₋₆ alkynyl and -OR⁷;Rˣ ’is selected from hydrogen, halogen, or substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₂₋₆ alkenyl and substituted or unsubstituted C₂₋₆ alkynyl; R⁷ is selected from hydrogen, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₂₋₆ alkenyl and substituted or unsubstituted C₂₋₆ alkynyl; R¹ ’is selected from substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₂₋₆ alkenyl, substituted or unsubstituted C₂₋₆ alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl;R² is selected from hydrogen, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₂₋₆ alkenyl, substituted or unsubstituted C₂₋₆ alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl ; R³ and R³ ’are independently selected from hydrogen, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₂₋₆ alkenyl and substituted or unsubstituted C₂₋₆ alkynyl; alternatively, R³ and R³ ’considered together with the connecting C atom can form a substituted or unsubstituted cycloalkyl;R⁴ and R⁴ ’are independently selected from hydrogen, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₂₋₆ alkenyl, substituted or unsubstituted C₂₋₆ alkynyl, -CHOR⁹ and -C (O) OR⁹;where R⁹ is selected from hydrogen, substituted or unsubstituted C₁₋₉ alkyl, substituted or unsubstituted C₂₋₉ alkenyl and substituted or
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