OLIGONUCLEOTIDES D'INVERSION DE L'IMMUNOSUPPRESSION INHIBANT L'EXPRESSION DE CD39

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专利权人:

SECARNA PHARMACEUTICALS GMBH & CO. KG

发明人:

JASCHINSKI, FRANK,HILMENYUK, TAMARA,THELEMANN, TAMARA

申请号：

CA3039068

公开号：

CA3039068A1

申请日:

2017.10.09

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present invention refers to immunosuppression-reverting oligonucleotides comprising 12 to 18 nucleotides, wherein at least one of the nucleotides is modified, and the oligonucleotide hybridizes with a nucleic acid sequence of an ectonucleotidase (NTPdase； CD73) of SEQ ID NO.1 (human), wherein the oligonucleotide inhibits at least 50 % of the CD39 expression. The invention is further directed to a pharmaceutical composition comprising such oligonucleotide.

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