Control of protein glycosylation by culture medium supplementation and cell culture process parameters

• 收藏
• 分享

专利权人:

Biogen MA Inc.;Samsung Bioepis

发明人:

Yang William,Huang Yao-Ming,McElearney Kyle,Tescione Lia,Lambropoulos James,Zhang An,Tsang Valerie,Ryll Thomas,Lee Sangil,Lee Dae Sung

申请号：

US201615000522

公开号：

US9944968(B2)

申请日:

2016.01.19

申请国别(地区):

美国

年份:

2018

代理人:

Wolf, Greenfield & Sacks, P.C.

摘要：

The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/