The invention relates to the use of one or more cannabinoids, particularly THC and/ or CBD in combination with a non-cannabinoid chemotherapeutic agent in the manufacture of a medicament for use in the treatment of cancer. In particular the cancer to be treated is a brain tumour, more particularly a glioma, more particularly still a glioblastoma multiforme (GBM). The non-cannabinoid chemotherapeutic agent may be a selective estrogen receptor modulator or an alkylating agent.本發明係有關於與一種非大麻素化學治療劑組合之一或多種大麻素及尤其是THC及/或CBD在製造用於治療癌症的一藥物之用途。尤其,待治療的癌症係一種腦腫瘤,更詳細地係一種神經膠質瘤,又更詳細地係一種多形性神經膠質母細胞瘤(GBM)。該非大麻素化學治療劑可為一種選擇性雌激素受體調控劑或一種烷基化劑。