Michael C. Wolf;Benhur Lee;Tinghu Zhang;Michael E. Jung
发明人:
Benhur Lee,Michael E. Jung,Michael C. Wolf,Tinghu Zhang
申请号：
US13000310
公开号：
US20120219613A1
申请日:
2009.06.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided herein are a series of arylmethylidene rhodanine derivatives having broad-spectrum antiviral activity against enveloped viruses, including but not limited to filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, influenza A, and HIV-1. The compounds act via a novel mechanism to disrupt viral membranes and inhibit viral attachment, fusion, and/or entry into host cells. The membrane disrupting activity of the compounds is selective for viral membranes relative to other biological membranes, making the compounds non-toxic to cells and host subjects.
