There is provided a cartridge medication dispensing apparatus having an auto locking function, the cartridge including a cartridge case having an open outlet on the bottom thereof so as to dispense medication a drum installed inside of the cartridge case so as to selectively open and/or close the outlet a cartridge base having the cartridge case installed thereto and a driving means connected to the drum and configured to drive the drum to be rotated, wherein a hollow cylinder having a coupling groove drilled therein is formed at a center of a bottom of the drum, a lifting body having an elastic protrusion elastically coupled to the coupling groove is inserted into the cylinder, wherein, when a rotation shaft of the driving means is inserted into the cylinder, the lifting body moves upward and then the elastic protrusion is separated from the coupling groove, whereas, when the rotation shaft of the driving means is separated from the cylinder, the lifting body moves downward and then the elastic protrusion is coupled to the coupling groove.