There is provided a cartridge for a medication dispensing apparatus having an auto locking function, the cartridge including a cartridge case a drum a cartridge base and a driving means, wherein a hollow cylinder having a coupling groove drilled therein is formed at a center of a bottom of the drum, a lifting body having an elastic protrusion elastically coupled to the coupling groove is inserted into the cylinder, wherein, when a rotation shaft of the driving means is inserted into the cylinder, the lifting body moves upward and then the elastic protrusion is separated from the coupling groove, whereas, when the rotation shaft of the driving means is separated from the cylinder, the lifting body moves downward and then the elastic protrusion is coupled to the coupling groove.