8-BETA-SUBSTITUTED ESTRATRIES AS SELECTIVELY ACTIVE ESTROGENS

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专利权人:

BAYER INTELLECTUAL PROPERTY GMBH

发明人:

PETERS, OLAF,THIEME, INA,PRELLE, KATJA,MUHN, HANS-PETER,FRITZEMEIER, KARL-HEINRICH,BRAEUER, NICO

申请号：

DK08775031

公开号：

DK2176282T3

申请日:

2008.07.11

申请国别(地区):

DK

年份:

2012

代理人:

摘要：

The invention refers to 8²-substituted estra-1,3,5(10)-triene derivatives of general formula I their use as pharmaceutical active ingredients, which have in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo a preferential action in the ovary in comparison to the uterus, their production, their therapeutic use and pharmaceutical dispensing forms that contain the new compounds.

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