8-beta-substituirani 16 alfa-fluoro-estratrieni kot selektivno aktivni estrogenic

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专利权人:

BAYER INTELLECTUAL PROPERTY GMBH

发明人:

PETERS OLAF,BRAEUER NICO,THIEME INA,PRELLE KATJA,MUHN HANS-PETER,FRITZEMEIER KARL-HEINRICH,PETERS Olaf,BRAEUER Nico,THIEME Ina,PRELLE Katja,MUHN Hans-Peter,FRITZEMEIER Karl-Heinrich

申请号：

SI200830826

公开号：

SI2176282T1

申请日:

2008.07.11

申请国别(地区):

SI

年份:

2013

代理人:

摘要：

The invention refers to 8²-substituted estra-1,3,5(10)-triene derivatives of general formula I their use as pharmaceutical active ingredients, which have in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo a preferential action in the ovary in comparison to the uterus, their production, their therapeutic use and pharmaceutical dispensing forms that contain the new compounds.

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