1 - oxo - (2,6 - dioxopiperidine - yl) - 4 - aminoisoindoline, optionally in the form of a salt of pharmaceutically acceptable addition salt, and either:

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专利权人:

CELGENE CORPORATION

发明人:

MULLER George, W.,STIRLING David, I.,CHEN Roger, Shen-Chu

申请号：

LU91359

公开号：

LU91359I9

申请日:

2007.09.06

申请国别(地区):

LU

年份:

2018

代理人:

摘要：

Substituted 2-(2,6-dioxopiperidin-3-yl)phtalimides and l-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF alpha in a mammal. Typical embodiments are 1-oxo-2(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.

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