MANGANESE SUPEROXIDE DISMUTASE EXON 3-DELETED ISOFORMS AND NUCLEIC ACID MOLECULES ENCODING THE ISOFORMS

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专利权人:

ANZIANO PAUL Q

发明人:

ANZIANO PAUL Q.

申请号：

US20070757685

公开号：

US2010199367(A1)

申请日:

2007.06.04

申请国别(地区):

美国

年份:

2010

代理人:

摘要：

A new isoform of manganese superoxide dismutase (MnSOD) and polynucleotides encoding it have been identified. This isoform, MnSOD E3(−), is a splice variant lacking exon 3 of the full length MnSOD. The polypeptide can be expressed using appropriate host cells. Modulation of either the expression of the polynucleotides of the activity of the polypeptide is also described. Furthermore, diagnostic and therapeutic methods have been developed as a consequence of the isolation of the polynucleotides and polypeptides.

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