Bone regeneration membrane (1) comprising:- a dense layer (2) made of resorbable polymer, said dense layer (2) having first and second opposite surfaces and being adapted to form a barrier to cells and soft tissues,- a nanofibrillar layer (3) made of resorbable polymer and attached to the first surface of the dense layer (2), said nanofibrillar layer comprising fibers having a diameter of nanometer size, said fibers being interlaced so as to present an average pore size greater than 10 µm to allow cell permeability and bone tissue regeneration.
