SYNTHESIS OF PRODRUGS OF IBUPROFEN AND NANOPARTICLES PREPARATION USING POLY (L-LACTIDE) FOR CONTROLLED DRUG RELEASE

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专利权人:

发明人:

BAIJAYANTIMALA GARNAIK

申请号：

IN201611026727

公开号：

IN201611026727A

申请日:

2016.08.05

申请国别(地区):

IN

年份:

2018

代理人:

摘要：

The present invention discloses a process for the synthesis of alkyl ester pro drugs of Ibuprofen of formula (I) and its encapsulation with polymeric nanoparticles for controlled drug release. More particularly, the present invention discloses a process for the synthesis of alkyl ester prodrugs of Ibuprofen of formula (I) from respective alcohols with increased pharmacological activity, low ulcerogenicity and good chemical stability. Further, the present invention discloses the study of said drug in vitro and in vivo controlled release pattern. Formula (I)

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