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-2- --2- INDOLIN-2-ONE OR PYRROLO-PYRIDIN-2-ONE DERIVATIVES
专利权人:
에프. 호프만-라 로슈 아게
发明人:
힐페르트 한스,콜체브스키 사비네,훔 롤란드,스톨 테오도르,뮤저 토르스텐,플랑셰 장-마르크,가우프레투 델핀느
申请号:
KR1020177002270
公开号:
KR1018194330000B1
申请日:
2015.06.23
申请国别(地区):
KR
年份:
2018
代理人:
摘要:
The present invention is directed to 2-oxo-2,3-dihydro-indole of formula (I), or a pharmaceutically acceptable salt, racemic mixture, or a corresponding enantiomer and / or optical isomer and / or stereoisomer thereof It is about: (I) In this formula, Ar 1 is phenyl or a 5 or 6 membered heteroaryl group containing 1, 2 or 3 heteroatoms selected from N, S or O, wherein the N-heteroatom in the heteroaryl group is N + - (O - ) Can be oxidized; R 1 is lower alkyl, halogen, cyano or cycloalkyl; Ar 2 is a 5 or 6 membered heteroaryl group containing 1, 2, 3 or 4 heteroatoms selected from N, S or O, wherein the N-heteroatom in the heteroaryl group is oxidized to N + - (O - ) Or Ar <; 2 >; is benzo [b] thiophenyl; R 2 is selected from the group consisting of hydrogen, lower alkyl, halogen, cyano, lower alkyl substituted with hydroxy, lower alkyl substituted with halogen, lower alkyl substituted with amino, lower alkyl substituted with alkoxy, Cycloalkyl; X is CH or N; n is 1 or 2; m is 1 or 2; The compounds are useful for the treatment and / or prevention of schizophrenia, including, but not limited to, positive symptom (psychosis) and negative symptoms, drug abuse, alcohol and drug addiction, obsessive compulsive disorder, cognitive impairment, bipolar disorder, mood disorder, major depression, , Parkinson's disease, chronic pain, borderline personality disorder, neurodegenerative disease, sleeping disorder, chronic fatigue syndrome, stiffness, inflammatory disease, asthma, Huntington's disease, ADHD, amyotrophic lateral sclerosis, , Viral and fungal infections, cardiovascular diseases, ophthalmic and inflammatory retinal diseases or balance disorders.본 발명은 하기 화학식 I의 2-옥소-2,3-다이하이드로-인돌, 또는 이의 약학적으로 허용되는 염, 라세미 혼합물, 또는 이의 상응하는 거울상 이성질체 및/또는 광학 이성질체 및/또는 입체 이성질체에 관한 것이다:[화학식 I]상기 식에서,Ar1은 페닐, 또는 N, S 또는 O로부터 선택된 1, 2 또는 3개의 헤테로 원자를 함유하는 5원 또는 6원 헤테로아릴 기이되,헤테로아
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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