Lyophilised and aqueous anti-CD40 antibody formulations

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专利权人:

Novartis AG

发明人:

Mueller, Claudia,Willmann, Matthias

申请号：

AU2016204371

公开号：

AU2016204371B2

申请日:

2016.06.24

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

#$%^&*AU2016204371B220171026.pdf#####H: rec Intrwovn NRPortbl DCC REC l0376410_ .docx-24/06/2016 ABSTRACT Anti-CD40 antibodies are formulated as lyophilisate or liquid formulation. The lyophilisates can be reconstituted to give a solution with a high concentration of the antibody active ingredient for delivery to a patient without high levels of antibody aggregation. The lyophilisate can be reconstituted with an aqueous reconstituent to provide an aqueous composition in which the antibody has a concentration of at least 50mg/ml. The lyophilisate or aqueous pharmaceutical composition may include one or more of a sugar, a buffering agent, a surfactant, and/or a free amino acid.

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