#$%^&*AU2016256808A120161201.pdf#####H:\rec\Interwoven\NRPortbl\DCC\REC\19572701 .docx-10/l11/2016 Abstract The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. More particularly, the invention relates to combined therapies for treating said disease by decreasing PMP22 expression in a subject.