The present Invention relates to a compound of formula (i) or a pharmaceutically acceptable Salt thereof where: ar is phenyl, piridilo, among others r1 is alkyl or fluoroalquilo C1 - C3 C1 - C3 R2 is H, halogen, among others R3 is C1 - C3 alkyl or a Salt of this.Preferred compounds are n - (3 - ((2R, 5R) - 6 - amino - 3,3,5 - trifluoro - 2,5 - dimethyl - 2 - tetrahidropiridin 2,3,4,5 - yl) - 4-fluorophenyl) - 5 - fluoropicolinamida n - (3 - ((2R, 5R) - 6 - amino - 3,3,5 - trifluoro - 2,5 - dimethyl - 2 - tetrahidropiridin 2,3,4,5 - yl) - 4-fluorophenyl) - 5 - cloropicolinamida, among others. These compounds inhibit BACE1 Enzyme and are useful in the treatment of Alzheimers diseaseLa presente invencion se refiere a un compuesto de formula (I) o una sal de la misma farmaceuticamente aceptable donde: Ar es fenilo, piridilo, entre otros R1 es alquilo C1-C3 o fluoroalquilo C1-C3 R2 es H, halogeno, entre otros R3 es alquilo C1-C3 o una sal de este. Son compuestos preferidos N-(3-((2R,5R)-6-amino-3,3,5-trifluoro-2,5-dimetil-2,3,4,5-tetrahidropiridin-2-il)-4-fluorofenil)-5-fluoropicolinamida N-(3-((2R,5R)-6-amino-3,3,5-trifluoro-2,5-dimetil-2,3,4,5-tetrahidropiridin-2-il)-4-fluorofenil)-5-cloropicolinamida, entre otros. Dichos compuestos inhiben la enzima BACE1 y son utiles en el tratamiento del Alzheimer
