PROBLEM TO BE SOLVED: To provide an information processing apparatus, an information processing method, and a surgical microscope system that are capable of presenting appropriate operation guide information in an eye operation.SOLUTION: An information processing apparatus includes an image recognition unit and a controller. The image recognition unit is configured to perform image recognition on an intraoperative image of an eye as an operation target which is acquired during an operation. The controller is configured to determine a cross-section for acquiring a tomographic image of the eye as an operation target, based on a result of recognition by the image recognition unit.SELECTED DRAWING: Figure 16COPYRIGHT: (C)2016,JPO&INPIT【課題】眼の施術において適切な施術ガイド情報を提示することが可能な情報処理装置、情報処理方法及び手術顕微鏡装置を提供すること。【解決手段】本技術に係る情報処理装置は、画像認識部と、制御部とを具備する。画像認識部は、施術対象の眼について術中に取得された術中画像に対して画像認識を行う。制御部は、画像認識部による認識結果に基づいて、施術対象の眼の断層画像を取得するための断層面を決定する。【選択図】図16