Disclosed herein are methods of treating pancreatic cancer and/or multiple myeloma cancer in a subject, comprising: providing a composition comprising a micelle construct attached to curcumin and treating pancreatic cancer and/or multiple myeloma cancer in the subject by administering a therapeutically effective dosage of the composition to the subject. Further disclosed herein are pharmaceutical compositions, comprising: an inhibitor of NF-kB a glut-1 antibody and a pharmaceutically acceptable carrier. Also disclosed herein are methods of using the same.