Frans Eduard Janssens;Sophie Coupa;Alain Philippe Poncelet;Yvan Rene Ferdinand Simonnet;Bruno Schoentjes
发明人:
Frans Eduard Janssens,Sophie Coupa,Alain Philippe Poncelet,Yvan Rene Ferdinand Simonnet,Bruno Schoentjes
申请号：
US11886175
公开号：
US08604200B2
申请日:
2006.03.03
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention concerns substituted diaza-spiro-[4.4]-nonane derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment and/or prophylaxis of schizophrenia, emesis, anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disturbances, pre-eclampsia, nociception, pain, in particular visceral and neuropathic pain, pancreatitis, neurogenic inflammation, asthma, chronic obstructive pulmonary disease (COPD) and micturition disorders such as urinary incontinence. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in claim 1.
