JANSSENS, FRANS EDUARD,COUPA, SOPHIE,PONCELET, ALAIN PHILIPPE,SIMONNET, YVAN RENE FERDINAND,SCHOENTJES, BRUNO
申请号：
CA2599186
公开号：
CA2599186C
申请日:
2006.03.03
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
This invention concerns substituted diaza-spiro-[4.4]-nonane derivativeshaving neurokinin antagonistic activity, in particular NK1 antagonist icactivity, their preparation, compositions comprising them and their use as amedicine, in particular for the treatment and/or prophylaxis of schizophrenia,emesis, anxiety and depression, irritable bowel syndrome (IBS), circadianrhythm disturbances, pre-eclampsia, nocicept ion, pain, in particular visceraland neuropathic pain, pancreatitis, neurogenic inflammation, asthma, chronicobstructive pulmonary disease (COPD) and micturition disorders such as urinaryincont inence. The compounds according to the invention can be represented bygeneral Formula (I) and comprises also the pharmaceutically acceptable acid orbase addition salts thereof, the stereochemically isomeric forms thereof, theN-oxide form thereof and prodrugs thereof, wherein all substituents aredefined as in Claim 1.
