Compounds of formula (I), are aurora kinase inhibitors: wherein X is —N—, —CH2-N—, —CH2-CH—, or —CH—； R1 is a radical of formula (IA) wherein Z is —CH2-, —NH—, -0-, —S(O)— —S—, —S(O)2 or a divalent monocyclic carbocyclic or heterocyclic radical having 3-7 ring atoms； Alk is an optionally substituted divalent C1-C6 alkylene radical； A is hydrogen or an optionally substituted monocyclic carbocyclic or heterocyclic ring having 5-7 ring atoms； r, s and t are independently 0 or 1, provided that when A is hydrogen then at least one of r and s is 1； R2 is halogen, —CN, —CF3, —OCH3, or cyclopropyl； and R3 is a radical of formula (IB) wherein Q is hydrogen or an optionally substituted phenyl or monocyclic heterocyclic ring with 5 or 6 ring atoms； Z&It；1>； is —S—, —S(O)—, —S(O)2-, —O—, —SO2NH—, —NHSO2-, NHC(═O)NH, —NH(C═S)NH—, Or —N(R4)— wherein R4 is hydrogen, C1-C3 alkyl, cycloalkyl, or benzyl； and Alk&It；1>； and Alk&It；2>； are, independently, optionally substituted divalent C1-C3 alkylene radicals； and m, n and p are independently 0 or 1.
