Artem Tcherkassov,Paul Rennie,Fuqiang Ban,Huifang Li,Eric Joseph Jean LeBlanc,Kush Dalal,Anton V. Tverdokhlebov,Sergiy Babiy,Evgeniia Bogomol,Kateryna Dunayenko
申请号：
US15118652
公开号：
US10011573B2
申请日:
2015.02.13
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A compound having the structure of Formula I, wherein A is a substituted or unsubstituted aryl or heteroaryl group, D is a substituted or unsubstituted 5- or 6-membered heteroaryl or heterocyclyl group and E is a substituted or unsubstituted aryl, heteroaryl, cycloalkyl or heterocyclyl group. The compounds are used for the treatment of androgen modulated indications including cancer (prostate, breast, ovarian, endometrial or bladder cancer), hair loss, acne, hirsutism, ovarian cysts, polycystic ovary disease, precocious puberty and age related macular degeneration. The use of the compounds for the manufacture of a medicament for modulating AR activity, a method of treatment using such compounds and a pharmaceutical composition and a commercial package comprising said compounds are also described.
