Tcherkassov, Artem,Rennie, Paul S.,Ban, Fuqiang,Li, Huifang,Leblanc, Eric Joseph Jean,Dalal, Kush,Tverdokhlebov, Anton V.,Babiy, Sergiy,Bogomol, Evgeniia,Dunayenko, Kateryna
申请号：
AU2015218140
公开号：
AU2015218140A1
申请日:
2015.02.13
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
A compound having the structure of Formula I, wherein A is a substituted or unsubstituted aryl or heteroaryl group, D is a substituted or unsubstituted 5- or 6-mcmbcrcd heteroaryl or heterocyclyl group and E is a substituted or unsubstituted aryl, heteroaryl, cycloalkyl or heterocyclyl group. The compounds are used for the treatment of androgen modulated indications including cancer (prostate, breast, ovarian, endometrial or blader cancer), hair loss, acne, hirsutism, ovarian cysts, polycystic ovary disease, precocious puberty and age related macular degeneration. The use of the compounds for the manufacture of a medicament for modulating AR activity, a method of treatment using such compounds and a pharmaceutical composition and a commercial package comprising said compounds arc also described.
