COADY, DANIEL JOSEPH,DIPIETRO, RICHARD ANTHONY,ENGLER, AMANDA CATHERINE,HEDRICK, JAMES LUPTON,NG, VICTOR W.L.,ONG, ZHAN-YUIN,TAN, JEREMY P.K.,YANG, YI YAN
申请号：
SG11201508338V
公开号：
SG11201508338VA
申请日:
2014.03.27
申请国别(地区):
SG
年份:
2015
代理人:
摘要：
Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.
