INTERNATIONAL BUSINESS MACHINES CORPORATION;AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人:
Daniel J. Coady,Richard A. Dipietro,Amanda C. Engler,James L. Hedrick,Victor W. L. Ng,Zhan-Yuin Ong,Jeremy P. K. Tan,Yi Yan Yang
申请号：
US13859048
公开号：
US20140301968A1
申请日:
2013.04.09
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.
