蛋白質酪胺酸激酶活性抑制劑农业专利-农业学术服务平台

发明人:: CLARIDGE, STEPHEN WILLIAM,史帝芬　威廉　克拉吉,ISAKOVIC, LJUBOMIR,勒杰博米尔　伊萨科维克,勒傑博米爾　伊薩科維克,MANNION, MICHAEL,麦可　曼尼恩,麥可　曼尼恩,RAEPPEL, STEPHANE,史黛芬　瑞波,SAAVEDRA, OSCAR MARIO,奥斯卡　马力欧　沙维达,奧斯卡　馬力歐　沙維達,史帝芬威廉克拉吉,勒杰博米尔伊萨科维克,勒傑博米爾伊薩科維克,麦可曼尼恩,麥可曼尼恩,史黛芬瑞波,奥斯卡马力欧沙维达,奧斯卡馬力歐沙維達

摘要：: This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling and HGF receptor signaling. More particularly, the invention relates to compounds, compositions and methods for the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.本發明係關於會抑制蛋白質酪胺酸激酶活性之化合物。特定言之，本發明係關於化合物，其會抑制生長因子受體之蛋白質酪胺酸激酶活性，而造成受體發出訊息之抑制，例如，VEGF受體發出訊息與HGF受體發出訊息之抑制。更特定言之，本發明係關於抑制VEGF受體發出訊息與HGF受體發出訊息之化合物、組合物及方法。本發明亦提供關於治療細胞增生疾病與症狀之組合物與方法。