布魯頓氏（ＢＲＵＴＯＮ’Ｓ）酪胺酸激酶抑制劑农业专利-农业专业知识服务系统

发明人:: BROTHERTON-PLEISS, CHRISTINE E.,巴松顿　布列斯　克里斯汀Ｅ,巴松頓　布列斯　克里斯汀Ｅ,HILGENKAMP, RAMONA,希尔甘普　雷梦娜,希爾甘普　雷夢娜,KONDRU, RAMA K.,柯德鲁　雷玛Ｋ,柯德魯　雷瑪Ｋ,LOPEZ-TAPIA, FRANCISCO JAVIER,罗培兹　塔比亚　法兰西斯科　嘉维尔,羅培茲　塔比亞　法蘭西斯科　嘉維爾,LOU,,巴松顿布列斯克里斯汀E,巴松頓布列斯克里斯汀E,希尔甘普雷梦娜,希爾甘普雷夢娜,柯德鲁雷玛K,柯德魯雷瑪K,罗培兹塔比亚法兰西斯科嘉维尔,羅培茲塔比亞法蘭西斯科嘉維爾

摘要：: This application discloses compounds according to generic Formula I:wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.本申請案揭示通式I之化合物：其中所有變數均如本文中所定義，其抑制Btk。本文揭示之化合物適用於調節Btk活性，及治療與過度Btk活性有關之疾病。該等化合物亦適用於治療與異常B細胞增殖有關之發炎及自體免疫疾病，諸如類風濕性關節炎。亦揭示含有式I化合物及至少一種載劑、稀釋劑或賦形劑之組合物。