蛋白質酪胺酸激酶活性抑制劑农业专利-农业学术服务平台

发明人:: MANNION, MICHAEL,马尼恩　麦可,馬尼恩　麥可,雷普尔　史堤芬妮,雷普爾　史堤芬妮,CLARIDGE, STEPHEN WILLIAM,卡瑞奇　史堤芬　威廉,葛堤　弗德瑞克,ZHAN, LIJIE,詹力吉,ISAKOVIC, LJUBOMIR,艾萨科维　杰波米尔,艾薩科維　傑波米爾,SAAVEDRA, OSCAR MARIO,莎亚德拉　奥,马尼恩麦可,馬尼恩麥可,雷普尔史堤芬妮,雷普爾史堤芬妮,卡瑞奇史堤芬威廉,葛堤弗德瑞克,艾萨科维杰波米尔,艾薩科維傑波米爾,莎亚德拉奥

摘要：: This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling. The invention also provides compounds, compositions and methods for treating cell proliferative diseases and conditions and opthalmological diseases, disorders and conditions.本發明係關於會抑制蛋白質酪胺酸激酶活性之化合物。特定言之，本發明係關於化合物，其會抑制生長因子受體之蛋白質酪胺酸激酶活性，而造成受體發出訊息之抑制，例如，VEGF受體發出訊息之抑制。本發明亦提供關於治療細胞增生疾病與症狀及眼科學疾病、病症及症狀之化合物、組合物及方法。