INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY农业专利-农业学术服务平台

发明人:: 雷普尔史堤芬妮,雷普爾史堤芬妮,RAEPPEL, FRANCK,瑞波法兰克,瑞波法蘭克,CLARIDGE, STEPHEN WILLIAM,卡瑞奇史堤芬威廉,卡瑞奇史堤芬威廉,ZHAN, LIJIE,詹力吉,詹力吉,葛堤弗德瑞克,葛堤弗德瑞克,MANNION, MICHAEL,马尼恩麦可,馬尼恩麥可,SATO, NORIFUMI,佐藤范典,佐藤範典,YUKI, YOHEI

摘要：: This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling. The invention also provides compounds, compositions and methods for treating cell proliferative diseases and conditions and ophthalmic diseases, disorders and conditions.本發明係關於抑制蛋白質酪胺酸激酶活性之化合物。特定言之,本發明係關於抑制生長因子受體之蛋白質酪胺酸激酶活性,從而抑制受體信號傳導(例如抑制VEGF受體信號傳導)之化合物。本發明亦提供治療細胞增殖性之疾病及病狀以及眼科之疾病、病症及病狀之化合物、組合物及方法。