Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.ビロキサジン及びその様々な塩、並びにその新規な中間体反応生成物及び多形等のビロキサジン関連の化合物を製造する方法が提供される。特に本方法は、望ましくない不純物を避けながらビロキサジンＨＣｌの実質的に純粋なＡＰＩを提供する。本方法は更に、ビロキサジンの新規な多形の分離、特定及び特性化を提供する。ビロキサジン、並びにビロキサジンの一部の重要な代謝産物及び代謝産物の前駆体の新規な中間体の合成及び特定及び特性化のための方法が更に提供される。【選択図】図４
