WILSON, NICHOLAS STUART,WAIGHT, JEREMY DALE,JENNINGS, SHAWN MICHAEL,IGNATOVICH, OLGA,BRIEND, EMMANUEL CYRILLE PASCAL,MORIN, BENJAMIN MAXIME,SCHON, OLIVER,CAMPBELL, SPENCER
申请号：
CA3093468
公开号：
CA3093468A1
申请日:
2019.03.08
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The instant disclosure provides antibodies that specifically bind to CD73 (e.g., human CD73) and antagonize CD73 function. Also provided are anti-CD73 antibodies that further comprise a TGFß-binding moiety or a VEGF-binding moiety. The instant disclosure additionally provides pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
