KONTEATIS, Zenon D.,LI, Mingzong,LIU, Peng,MEDEIROS, Matthew,REZNIK, Samuel K.,SUI, Zhihua,TRAVINS, Jeremy M.,POPOVICI-MULLER, Janeta,ZHOU, Shubao,MA, Guangning
申请号：
AU2019243289
公开号：
AU2019243289A1
申请日:
2019.03.28
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present disclosure provides for compounds according to Formula I or Formula II and their pharmaceutically acceptable salts, stereoisomers, and/or tautomers thereof. Also provided are pharmaceutical compositions and the compounds of formulae I and II for use in methods of treating cancers, via inhibition of MAT2A, including some cancers in which the gene encoding methylthioadenosine phosphorylase (MTAP) is deleted and/or not fully functioning.
