KONTEATIS, ZENON D.,LI, MINGZONG,LIU, PENG,MEDEIROS, MATTHEW,REZNIK, SAMUEL K.,SUI, ZHIHUA,TRAVINS, JEREMY M.,ZHOU, SHUBAO,MA, GUANGNING,POPOVICI-MULLER, JANETA
申请号：
CA3094476
公开号：
CA3094476A1
申请日:
2019.03.28
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present disclosure provides for compounds according to Formula I or Formula II and their pharmaceutically acceptable salts, stereoisomers, and/or tautomers thereof. Also provided are pharmaceutical compositions and the compounds of formulae I and II for use in methods of treating cancers, via inhibition of MAT2A, including some cancers in which the gene encoding methylthioadenosine phosphorylase (MTAP) is deleted and/or not fully functioning.
