KIM, Yuntae,LEE, Chang Sik,OH, Jung Taek,SONG, Hyeseung,CHOI, Jin,LEE, Jaeyoung
申请号：
PH12018500773
公开号：
PH12018500773A1
申请日:
2018.04.10
申请国别(地区):
PH
年份:
2018
代理人:
摘要：
The present disclosure relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present disclosure have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases； neoplasms； endocrine, nutritional and metabolic diseases； mental and behavioral disorders； neurological diseases； diseases of the eye and adnexa； cardiovascular diseases； respiratory diseases； digestive diseases； diseases of the skin and subcutaneous tissue； diseases of the musculoskeletal system and connective tissue； or congenital malformations, deformations and chromosomal abnormalities.
