SENSIBILISATION DE PETITES MOLECULES A L'ACTIVATION DE BAX POUR L'INDUCTION DE LA MORT CELLULAIRE

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专利权人:

INC.;DANA-FARBER CANCER INSTITUTE

发明人:

WALENSKY, LOREN D.,PRITZ, JONATHAN,WACHTER, FRANZISKA

申请号：

CA3054452

公开号：

CA3054452A1

申请日:

2018.03.14

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

Provided herein are compositions comprising a compound of Formulas I, II, or III, and compositions a compound comprising a moiety of Formula IV, which are useful for sensitizing and/or activating pro-apoptotic activity of BAX. Methods of treating diseases associated with BAX (e.g., cancer) and methods of identifying compounds which sensitize and/or activate the pro-apoptotic activity of a BAX polypeptide are also provided.

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中国工程科技知识中心

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http://www.ckcest.cn/home/